Tumor Basal Area and Metastatic Death After Proton Beam Irradiation for Choroidal Melanoma

Tumor basal area and metastatic death after proton beam irradiation for choroidal melanoma.

BACKGROUND Tumor dimension is an established prognostic factor for metastasis-related death after radiotherapy for uveal melanoma. OBJECTIVE To compare various methods of modeling the relationship between tumor dimension and metastatic death. PATIENTS AND METHODS The analyses were based on a consecutive series of 1204 patients with primary choroidal melanoma treated with proton beam irradia...

Metastatic melanoma death rates by anatomic site after proton beam irradiation for uveal melanoma.

BACKGROUND Ciliary body location is an established prognostic factor for metastasis-related death from uveal melanoma. We evaluated alternative approaches for classifying this covariate when constructing predictive models of patient survival. METHODS AND DESIGN The analyses were based on a consecutive series of 1848 primary choroidal and/or ciliary body melanoma patients treated with proton b...

Metastasis rates and sites after treatment for choroidal melanoma by proton beam irradiation or by enucleation

PURPOSE To investigate tumor thickness and location, the interval of time between treatment for choroidal melanoma (proton beam irradiation or enucleation) and diagnosis of metastatic disease, and rates and sites of metastasis. DESIGN Retrospective, interventional, noncomparative case series. METHODS Follow-up of 152 patients with primary choroidal melanoma, between 1992 and 2006 (14 years)...

Intraocular inflammation after proton beam irradiation for uveal melanoma.

AIM To describe the inflammatory reaction that can occur following proton beam irradiation of uveal melanomas based on a large series of patients and to try to determine the risk factors for this reaction. METHODS Data from a cohort of patients with uveal melanoma treated by proton beam irradiation between 1991 and 1994 were analysed. The presence of inflammation was recorded and evaluated. K...

Fulminant hepatic failure due to metastatic choroidal melanoma